Evaluation of paraoxonase 1 arylesterase activity and lipid peroxide levels in patients with type 1 diabetes

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Evaluation of paraoxonase 1 arylesterase activity and lipid peroxide levels in patients with type 1 diabetes.

INTRODUCTION Poor metabolic control of type 1 diabetes is one of the most important factors accelerating the development of late diabetic complications. Several other factors that might contribute to this process are currently being investigated. Low paraoxonase 1 (PON1) activity and high lipid peroxide (LPO) levels contribute to endothelial damage, but it remains unclear whether they are criti...

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PARAOXONASE AND ARYLESTERASE ACTIVITY AMONG HYPERCHOLESTEROLEMIC PATIENTS

Human serum paraoxonase (PON) associated with high density lipoprotein (HDL) , has been postulated to have a role in protecting low-density lipoprotein (LDL) against oxidative damage, which has led to the proposal that PON is an anti-atherogenic and anti-inflammatory enzyme. It has genetic polymorphism at the 191 (R ->Q) and two alloenzymes A and B and three phenotypes A, B, and AB. We exa...

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Paraoxonase-1 and arylesterase activities in patients with colorectal cancer.

BACKGROUND The aim of this study was to evaluate paraoxonase-1 (PON1) and arylesterase (ARE) activities and oxidative stress status in patients with colorectal carcinomas (CRC). MATERIALS AND METHODS Thirty-three patients (20 male, 13 female) with CRC and 30 healthy controls were enrolled in the study. Blood samples were obtained from the CRC patients before adjuvant therapy. Serum samples fr...

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Effect of Aerobic and Resistance Training on GDF-15 Levels in Patients with Type 1 Diabetes

Background and purpose: Increasing prevalence of diabetes and its complications, including cardiovascular problems increase the cost of health care which could be diminished with proper planning to change lifestyle. The present study investigated the effect of aerobic and resistance trainings on blood GDF15 level as a protective marker on cardiovascular cells in patients with type 1 diabetes. ...

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High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism.

Autism is a behaviorally defined disorder of unknown etiology that is thought to be influenced by genetic and environmental factors. High levels of homocysteine and oxidative stress are generally associated with neuropsychiatric disorders. The purpose of this study was to compare the level of homocysteine and other biomarkers in children with autism to corresponding values in age-matched health...

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ژورنال

عنوان ژورنال: Polish Archives of Internal Medicine

سال: 2011

ISSN: 1897-9483

DOI: 10.20452/pamw.1113